Abstract Search

ea0090p330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cabergoline counteracts adipose and skeletal muscle lipid accumulation through promoting oxidative pathway: an in vivo and in vitro preclinical study

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Paola Provvisiero Donatella , Simeoli Chiara , de Angelis Cristina , Simona Auriemma Renata , Colao Annamaria , Crescenzo Raffaella , Pivonello Rosario

Obesity, characterized by an abnormal body fat accumulation mainly caused by a chronic imbalance between energy intake and expenditure, is a massive public health problem. Targeting excessive fat deposition in adipose tissue and ectopic fat accumulation in skeletal muscle through promoting lipid oxidation pathway may represent a promising strategy to counteract obesity. This study aims at investigating the effects of cabergoline (CAB), a dopamine agonist, on adipose and skelet...

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ea0090p145 | Pituitary and Neuroendocrinology | ECE2023

Somatostatin receptor type 2 (SSTR2) expression regulation by miR-375 in a murine pituitary corticotroph tumor cell model

Pivonello Claudia , Patalano Roberta , Monto Tatiana , Negri Mariarosaria , Amatrudo Feliciana , Paola Provvisiero Donatella , Simeoli Chiara , Paola Nicola , Larocca Angelica , Massimo Crescenzo Erminio , Colao Annamaria , Pivonello Rosario

Cushings disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of hypercortisolism. Pituitary surgery is the first-line treatment of CD and medical treatment is an alternative second-line approach to control cortisol excess. Long-term exposure to glucocorticoids (GC) downregulates the expression of somatostatin receptor type 2 (SSTR2) but not type 5 (SSTR5) in human and mouse ACTH-secreting tumor cell cultures; t...

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ea0056p674 | Nuclear receptors and Signal transduction | ECE2018

1,25 dihydroxyvitamin D reverses everolimus resistance in hepatocellular carcinoma activating mesenchymal-epithelial transition and miR-375

Pivonello Claudia , Paola Provvisiero Donatella , Negri Mariarosaria , Di Gennaro Gilda , de Angelis Cristina , Patalano Roberta , Galdiero Giacomo , Simeoli Chiara , Simona Auriemma Renata , Cristina De Martino Maria , Colao Annamaria , Pivonello Rosario

HCC is a difficult-to-treat-cancer with poor prognosis. EVOLVE-1 trial demonstrated that EVE did not improve overall survival in molecularly and clinically unselected patients with advanced HCC resistant to sorafenib. In selected patients, the well-established antitumor effect of EVE could make this a potential adjuvant therapy. Unfortunately, EVE acquired resistance due to the tumor adaptation to chronic drug use is a current challenge. VitD was deemed as potential regimen to...

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Endocrine Abstracts

Cabergoline counteracts adipose and skeletal muscle lipid accumulation through promoting oxidative pathway: an in vivo and in vitro preclinical study

Somatostatin receptor type 2 (SSTR2) expression regulation by miR-375 in a murine pituitary corticotroph tumor cell model

1,25 dihydroxyvitamin D reverses everolimus resistance in hepatocellular carcinoma activating mesenchymal-epithelial transition and miR-375

BiosciAbstracts